{"id":8558,"date":"2022-06-02T21:52:10","date_gmt":"2022-06-02T19:52:10","guid":{"rendered":"http:\/\/mohnfoundation.webforslag.com\/prosjekt\/emmeth-mccormack\/"},"modified":"2022-12-07T14:56:34","modified_gmt":"2022-12-07T13:56:34","slug":"emmet-mc_cormack","status":"publish","type":"prosjekt","link":"https:\/\/mohnfoundation.no\/en\/prosjekt\/emmet-mc_cormack\/","title":{"rendered":"Emmet Mc Cormack"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row el_class=&#8221;article-white&#8221; css=&#8221;.vc_custom_1649536549777{margin-right: 0px !important;margin-left: 0px !important;}&#8221;][vc_column][vc_row_inner][vc_column_inner]<div class=\"spacer-f96c97828f0d47b1724343c705ecae9d423\" style=\"\"><\/div><style>@media (min-width: 320px) { .spacer-f96c97828f0d47b1724343c705ecae9d423{ height: 10px;}}@media (min-width: 767px) { .spacer-f96c97828f0d47b1724343c705ecae9d423{ height: 10px;}}@media (min-width: 979px) { .spacer-f96c97828f0d47b1724343c705ecae9d423{ height: 10px;}}@media (min-width: 1200px) { .spacer-f96c97828f0d47b1724343c705ecae9d423{ height: 10px;}}<\/style><div class=\"header left  \"><h1 class=\"font-size-sm\" title=\"Emmet Mc Cormack\">Emmet Mc Cormack<\/h1><\/div>[\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=&#8221;3\/4&#8243;]\n                    <div class=\"info-container\">\n                        <div class=\"fields row\">  <div class=\"field1 col-lg-4 col-md-4 col-sm-12\">\n                                            <div class=\"field1-header\" >\n                                            BFS-project\n                                            <\/div >\n                                            <div class=\"field1-number\" >\n                                            In Vivo Imaging of Cancer \u2013 Diagnostic and Pharmaceutical Imaging\n                                            <\/div >\n                                        <\/div> <div class=\"field2 col-lg-4 col-md-4 col-sm-12\">\n                                            <div class=\"field2-header\" >\n                                            Period\n                                            <\/div >\n                                            <div class=\"field2-number\" >\n                                            2011 - 2014\n                                            <\/div >\n                                        <\/div> <div class=\"field3 col-lg-4 col-md-4 col-sm-12\">\n                                            <div class=\"field3-header\" >\n                                            Department\n                                            <\/div >\n                                            <div class=\"field3-number\" >\n                                            Department of Clinical Science\n                                            <\/div >\n                                        <\/div>\n                        <\/div>   \n                    <\/div>[vc_column_text]Professor Emmet Mc Cormack is PI of the research group Translational Molecular Imaging in Cancer. His main motivation is the development and effective translation of novel therapies and imaging strategies for the treatment of cancer, particularly cancers with limited therapeutic options. It is the group\u2019s belief that the current dogma of rushing novel pharmaceuticals through inappropriate preclinical models is one of the major reasons for their limited clinical penetration. This can only be solved through multidisciplinary development of preclinical surrogates, models and diagnostic tools that more accurately mimic clinical conditions. Subsequently, the group has lead the development of patient derived xenograft models in hematological malignancies (in collaboration with Professors \u00d8ystein Bruserud and Bj\u00f8rn Tore Gjertsen), gynecological cancers (in collaboration with Professor Line Bj\u00f8rge and Dr. Camilla Krakstad) and pancreatic cancer (in collaboration with Professor Anders Molven and Dr. Dag Hoem) in Bergen. The group now has multimodal imaging of over 40 personalized cancer models, spanning most cancer phenotypes in addition to lab-on-a-chip scaffolds for greater in vitro understanding of the bone marrow microenvironments. The group\u2019s work has featured in high impact journals such as Cell Stem Cell, PNAS, Leukemia, Blood, Cancer Res etc., been awarded substantial independent grants , and been recognized both nationally (Best Young Investigator 2014 \u2013 Norwegian Oncology Society) and globally (Best Young Investigator \u2013 World Molecular Imaging Society). Current projects include, SonoCURE (funding through NFR, NIH and Helse Vest) exploring the application of Sonoporation (the transient formation of pores in cells by microbubbles activated by ultrasound) in the treatment of pancreatic ductal adenocarcinoma. The application aims to elucidate, evaluate, and potentiate a new era of sonoporation theranostics for PDAC through application of innovative biomarker mining, organoid models and preclinical modelling. Clinical collaboration with researcher Kotopoulis, Professor Dimcevski and Professor Gilja are planned for a Phase II trial follow up from a very successful Phase I trial (Dimcevski et al. J Control Release 2016). A second major focus is the development of novel preclinical models of leukemia and lymphomas for novel targeted and immune- therapies (Li et al. Cell Stem Cell 2014), with exploration of microenvironmental factors critical to disease development. Finally, the group is developing the application of image-guided surgery (Helland et al. PLoS One 2016), whereby fluorescent dyes will target biomarkers on surgically amenable cancers to aid their greater resection. This is particularly relevant to gynecological cancers and sarcomas.[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/4&#8243;]\n\t\t\t<figure class=\"standard-image left no-caption\">\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"534\" height=\"350\" src=\"https:\/\/mohnfoundation.no\/wp-content\/uploads\/2022\/06\/Emmeth-Mc-Gormack-2-e1497967793406.jpg\" class=\"attachment-img-xxl size-img-xxl\" alt=\"\" srcset=\"https:\/\/mohnfoundation.no\/wp-content\/uploads\/2022\/06\/Emmeth-Mc-Gormack-2-e1497967793406.jpg 534w, https:\/\/mohnfoundation.no\/wp-content\/uploads\/2022\/06\/Emmeth-Mc-Gormack-2-e1497967793406-300x197.jpg 300w, https:\/\/mohnfoundation.no\/wp-content\/uploads\/2022\/06\/Emmeth-Mc-Gormack-2-e1497967793406-320x210.jpg 320w, https:\/\/mohnfoundation.no\/wp-content\/uploads\/2022\/06\/Emmeth-Mc-Gormack-2-e1497967793406-420x275.jpg 420w\" sizes=\"auto, (max-width: 534px) 100vw, 534px\" \/>\n\t\t\t\t\n\t\t\t<\/figure><div class=\"external-links-container blue-arrow-right\"><ul class=\"external-links\"><li class=\"inner-item\"><i class=\"fa fa-external-link\"><\/i><a href=\"https:\/\/www.uib.no\/en\/persons\/Emmet.Mc.Cormack\" target=\"_blank\" rel=\"noopener\">Homepage at the University of Bergen<\/a><\/li><li class=\"inner-item\"><i class=\"fa fa-external-link\"><\/i><a href=\"https:\/\/www.cristin.no\/as\/WebObjects\/cristin.woa\/wa\/personVis?type=PERSON&amp;pnr=425427&amp;la=no&amp;instnr=184\" target=\"_blank\" rel=\"noopener\">Publications registered in CRIStin<\/a><\/li><\/ul><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column]<div class=\"spacer-f4de40bb4e7b53dd110c90e1adcadb9a23\" style=\"\"><\/div><style>@media (min-width: 320px) { .spacer-f4de40bb4e7b53dd110c90e1adcadb9a23{ height: 30px;}}@media (min-width: 767px) { .spacer-f4de40bb4e7b53dd110c90e1adcadb9a23{ height: 30px;}}@media (min-width: 979px) { .spacer-f4de40bb4e7b53dd110c90e1adcadb9a23{ height: 60px;}}@media (min-width: 1200px) { .spacer-f4de40bb4e7b53dd110c90e1adcadb9a23{ height: 60px;}}<\/style>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Professor Emmet Mc Cormack is PI of the research group Translational Molecular Imaging in Cancer. His main motivation is the development and effective translation of novel therapies and imaging strategies for the treatment of cancer, particularly cancers with limited therapeutic options. Start up 2011.  [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary vidiflex-read-more-link\" href=\"https:\/\/mohnfoundation.no\/en\/prosjekt\/emmet-mc_cormack\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"featured_media":5282,"template":"","categories":[39],"class_list":["post-8558","prosjekt","type-prosjekt","status-publish","has-post-thumbnail","hentry","category-projects"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/mohnfoundation.no\/en\/wp-json\/wp\/v2\/prosjekt\/8558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mohnfoundation.no\/en\/wp-json\/wp\/v2\/prosjekt"}],"about":[{"href":"https:\/\/mohnfoundation.no\/en\/wp-json\/wp\/v2\/types\/prosjekt"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mohnfoundation.no\/en\/wp-json\/wp\/v2\/media\/5282"}],"wp:attachment":[{"href":"https:\/\/mohnfoundation.no\/en\/wp-json\/wp\/v2\/media?parent=8558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mohnfoundation.no\/en\/wp-json\/wp\/v2\/categories?post=8558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}